The choice of contrast agent, each with unique pharmacokinetic properties and thus behavior in vivo, also vary greatly between studies. Differences in hardware such as the MRI field strength, coil setups and sequence types available at different institutions can affect the quality of the images acquired and constrain the choice of certain parameters such as the volume of interest, spatial and temporal resolution. This is in part because implementation and standardization of DCE-MRI is challenging. Īlthough several individual studies have demonstrated the promise of DCE-MRI as an imaging biomarker, widespread clinical adoption of this technique remains limited. The use of DCE-MRI has also been explored in other fields such as obstetrics and the neurosciences. Studies have especially focused on using DCE-MRI to characterize tumor phenotypes or to evaluate the response of tumors to therapy. Given the inherent leakiness of tumor blood vessels (which enhances the signal observed at the tumor site due to more CA leakage), the majority of DCE-MRI studies have focused on oncology applications. The physiological properties of the tissue of interest are inferred by analyzing the image signal change kinetics induced by the CA within the tissue region of interest (ROI).
#HAPE ROCKETSHIP SERIAL#
In particular, physiological information garnered from techniques such as diffusion MRI, blood oxygen-level dependent (BOLD) MRI, iron-oxide imaging, dynamic susceptibility MRI (DSC-MRI) and dynamic contrast-enhanced MRI (DCE-MRI) are being explored as imaging biomarkers in virtually all aspects of medicine, especially in oncology and neurological diseases.ĭCE-MRI involves the rapid serial acquisition of T1-weighted images before, during and after intravenous injection of a contrast agent (CA). The utility of dynamic magnetic resonance imaging (MRI) studies to diagnose diseases, characterize their progression, and evaluate treatment response is a topic of vigorous research. The availability of a flexible analysis tool will aid future studies using DCE-MRI.Ī public release of ROCKETSHIP is available at. ROCKETSHIP was designed to be easily accessible for the beginner, but flexible enough for changes or additions to be made by the advanced user as well. Its applicability to both preclinical and clinical datasets is shown.
#HAPE ROCKETSHIP SOFTWARE#
ConclusionĪ DCE-MRI software suite was implemented and tested using simulations. Applicability of ROCKETSHIP for both preclinical and clinical studies is shown using DCE-MRI studies of the human brain and a murine tumor model. Simulations also demonstrate the utility of the data-driven nested model analysis. Robustness of the software to provide reliable fits using multiple kinetic models is demonstrated using simulated data. ROCKETSHIP was implemented using the MATLAB programming language. ROCKETSHIP incorporates analyses with multiple kinetic models, including data-driven nested model analysis.
Here, we developed ROCKETSHIP, an open-source, flexible and modular software for DCE-MRI analysis. Few software tools are currently available that specifically focuses on DCE-MRI analysis with multiple kinetic models. However, analysis of DCE-MRI data is complex and benefits from concurrent analysis of multiple kinetic models and parameters.
The deluxe Rocket Ship is made from quality Baltic Birch plywood with non-toxic finishing and requires some easy assembly.Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a promising technique to characterize pathology and evaluate treatment response. It includes astronauts and alien toy figures, a wheeled robot, moon walker, magnetic spaceship utility vehicle, solar panel, planetary lander, and much more to stimulate endless pretend-play space adventure games for boys and girls. This large lift-off rocket play center will make your young space explorer's imagination skyrocket! The Rocket Ship comes with 20 play pieces and features mission control, a space lab and engineering lab, all connected by a working wooden elevator. Get ready for hours of imaginative play with this beautifully designed and amazingly detailed spaceship by Hape. Blast off to another world with this four-stage Rocket Ship complete with planetary lander! Conduct your very own imaginary deep-space voyage! Play with a playmate to come up with a space-faring story! Explain what your astronauts and aliens can do in all the different levels of the rocket ship!
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